Beilstein J. Org. Chem.2014,10, 134–140, doi:10.3762/bjoc.10.10
inhibitory activity. Interestingly, physalin H (1) disrupted GLI1 binding to its DNA binding domain, while the weak inhibitor physalin G (2) did not show inhibition of GLI1-DNA complex formation.
Keywords: Hedgehog inhibitor; Hedgehogsignal; natural products; physalins; Solanum nigrum; Introduction
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Graphical Abstract
Figure 1:
Schematic procedure of the constructed assay system; Tc (tetracycline), TetR (tetracycline represso...